  Misgivings as to what?

I am full loth to word the thing that is in my mind, and thou so near
to him in blood, my lord.  But craving pardon if I do offend, seemeth it
not strange that madness could so change his port and manner?--not but
that his port and speech are princely still, but that they _differ_,
in one unweighty trifle or another, from what his custom was aforetime.